Suppressive effect of melatonin administration on ethanol. Ganoderma lucidum pharmacopuncture for teating ethanol. By 5 min, hyperemia greatly intensified at some mucosal sites. Alphalipoic acid improves acetic acidinduced gastric ulcer. Antioxidative and antiinflammatory effects of water extract. Antiulcer and antioxidant activity of moringa oleifera. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. The albino rats of either sex were divided into five groups, each consisting of six rats. This agent is also effective as mucosal protection in treatment of nonacid depended models such as ethanol induced ulcer model 3, 7, 30. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, ado. Alphalipoic acid improves acetic acidinduced gastric. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n.
Research article gastroprotective effects of lion s mane. One hour after ethanol administration blood samples were. Studies on the mechanism of ethanolinduced gastric damage in rats. Research article ethanolinduced gastric ulcer in male.
Histological analyses and studies of antioxidant and antiinflammatory activities were. Gastroprotective effect of zingerone on ethanolinduced gastric. Gastroprotective activity of ethyl43,5ditertbutyl2. The preliminary phytochemical evaluation was carried out by standard methods. Evaluation of preventive effect of withania somnifera root extract against ethanol induced ulcers in rats. Central ghrelin 44000 ngrat dosedependently reduced ethanolinduced gastric ulcers by 3977%. Biochanin a gastroprotective effects in ethanolinduced. Conventional histology and immunohistochemistry for ghrelin, gastrin, and somatostatin were performed on gastric specimens from representative rats. In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. Pdf amelioration of ethanolinduced gastric ulcers in rats.
The effect of nicotine on ethanolinduced gastric ulcers in rats. To explore the possible mechanisms of action, we examined antioxidant defense enzymes e. Ethanol induced gu in animal model resembles the pathophysiology of human ulcer. Pdf antiulcerogenic effect of cuphea ignea extract. Gastroprotective effect of zingerone on ethanolinduced gastric ulcers in rats article pdf available in medicina kaunas, lithuania 553.
For each extract, adult wistar rats of either sex were marked, weighed and randomly assorted into eight groups with each group containing five rats. For acute toxicity test 300 mg kg 1 2pentadecanone was orally given to rats, followed by 2 weeks observation period to confirm the. Antioxidant effects of some drugs on ethanol induced ulcers author. They were kept in specially constructed cages to prevent coprophagia during and after the experiment. Pdf amelioration of ethanolinduced gastric ulcers in. Daniel hollander and his colleagues induced ulcer with ethanol in rats to evaluate the gastroprotective. Original article aripiprazole an atypical antipsychotic. To investigate the protective effects of berberine on ethanolinduced gastric ulcer in mice.
Diazoxide, a katp channel opener, prevented ethanolinduced. Acute exposure of the gastric mucosa of rats to ethanol can result in gastric lesions similar to those occurring in gastric ulcer. The anti ulcer activity of ethanolic extract of indigofera tinctoria fabaceae leaf eeit was investigated in indomethacin and ethanol induced ulcer models in wistar rats. Thus, the current study aimed to investigate the potential protective effects of dio against ethanolinduced gastric injury in rats. The gastro protective effects of cibotium barometz hair on. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat ijpt. Gastric ulcer was induced in overnight fasted rats that. We have investigated this mechanism in the rat stomach via gross morphologic, videomicroscopic, histochemical, and pharmacologic approaches. Moreover, the alcoholinduced decrease in stomach antioxidant enzyme activity found in the ulcer control group was prevented by exphy. Ethanol causes necrotic lesions that reduce gastrointestinal tract defensive factors like bicarbonate secretion and the production of mucus and its circulation 2224. Gastroprotective activity of aqueous carica papaya seed. The aim of this work was to investigate the antioxidant potential of some commonly used drugs bromocriptine, haloperidol and azithromycin on alcohol induced ulcers in the rat. This study aimed to evaluate acute toxicity and ulcer inhibitory effect of 2pentadecanone as a ketone bioactive compound against ethanolinduced gastric ulcer in sprague dawley rats.
Pdf gastroprotective effects of betanin against ethanol. Pdf gastroprotective effect of zingerone on ethanol. Introduction of peptic ulcer peptic ulcer is among the most predominant gastrointestinal diseases in the world and is characterized by ulceration in the stomach and duodenum. Several studies have investigated the effect of zingerone on various gastrointestinal diseases, including irritable bowel syndrome and diarrhea. Amelioration of ethanolinduced gastric ulcers in rats pretreated. The effect of oral administration of raw camel milk 5 mlkg b. Antiulcerogenic effect of cuphea ignea extract against. Evaluation of preventive effect of withania somnifera root. Indomethacin and ethanol induced ulcer models the common parameter determined was ulcer index. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins exphy against ethanolinduced gastric ulcers in rats. Oral administration of camel milk in rats with ethanolinduced gastric ulcer. Evaluation of antiulcer activity of methanolic extract of. Forty adult wistar rats of either sex were marked, weighed and randomly assorted into 5 groups ae with each group containing 8 rats.
Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal group, cmc as ulcer group, 20 mgkg of omeprazole. In the present study we investigated the gastroprotective effect of citrus sinensis peel aqueous extract cspe and hesperidin h in ethanol etoh induced oxidative stress and peptic ulcer in rats. The rats were fasted for 24 h, the separate groups. Rats were killed either with gastritis alone or thereafter at day 1, 3 or 6 after ulcer induction. Pdf gastroprotective effects of pistacia atlantica extract on. Concentrated ethanol causes gastric lesions by a mechanism that is poorly understood.
Methanol leaf extract of actinodaphne sesquipedalis. Administration with weac not only markedly increased the activities of cat, sod, and gsh, decreased the level of mda, but also reduced the productions of tnf. Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal. Protective effect of falcaria vulgaris extract on ethanol. Ethanol induced ulcer model 22 the ulcer was induced by administering ethanol. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced. Substances other also been shown to induce microcirculatory abnormalithan nicotine could contribute to these adverse reac ties. In this study, we determine the cytotoxic, antioxidant and gastroprotective effect of ethab against ethanolinduced gastric mucosal ulcer in rats. A doseeffect relation was constructed using the ethanolinduced gastric ulcer model in male wistar rats. Mda contents were evaluated in ethanolinduced ulcer in vivo. Within 1 min of contact, ethanol caused diffuse mucosal hyperemia. The effect of nicotine on ethanolinduced gastric ulcers. Mar 11, 2019 this study is aimed to evaluate the effect of zingerone on ethanolinduced gastric ulcers in rats. Groups six and seven had animals treated with folic acid 2 mgkg and 3 mgkg for twentyone days and omeprazole for the penultimate seven days respectively.
Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg. Research article ethanolinduced gastric ulcer in male wistar. Groups six and seven had animals treated with folic acid 2 mgkg and 3 mgkg for twentyone days and omeprazole for. Ghrelin protects against ethanolinduced gastric ulcers in. Jasminum sambac is used in folk medicine as the treatment of many diseases. Gastric ulcer index, microscopic score, elevated dna fragmentation and chemiluminescence. The number of proliferating and apoptotic cells, the mucosal mucus and prostaglandin e 2 pge 2 level were also determined.
Phycobiliproteins of arthrospira spirulina maxima have attracted attention because of their potential therapeutic antioxidant properties. Gastric emptying rate was calculated through the formula. Gastric ulcer index, microscopic score, elevated dna fragmentation and chemiluminescence levels of the saline. Meanwhile, overall control rats group one received distilled water, while ulcer control group group two received ethanol only. The present study was designed to investigate the cytoprotective and antiinflammatory properties of tertbutylhydroquinone tbhq, a nuclear factor erythroid 2related factor 2 nrf2 activator, against gastric mucosal damage induced by acute exposure of ethanol. Antiulcer and antioxidant activity of moringa oleifera lam. According to yonei and guth 1 the gastric submucosal microvascular disturbance resulting in local ische. This study is aimed to evaluate the effect of zingerone on ethanolinduced gastric ulcers in rats. Gastric ulcers were induced in sprague dawley rats using one oral dose of absolute ethanol 1. Folic acid supplementation ameliorates inflammation and. Pdf antiulcer activity of swietenia mahagoni leaf extract. Influence of gender difference and gastritis on gastric. Pdf gastroprotective effect of zingerone on ethanolinduced. Methanol leaf extract of actinodaphne sesquipedalis lauraceae enhances gastric defense against ethanolinduced ulcer in rats hanita omar,1,2 noraziah nordin,3 pouya hassandarvish,4 maryam hajrezaie,5 ainnul hamidah syahadah azizan,1 mehran fadaeinasab,6 nazia abdul majid,7 mahmood ameen abdulla,5 najihah mohd hashim,3 hapipah mohd ali1 1department of chemistry, faculty of.
As shown in figure 1, the ethanol 96% administration induced extensive long and hemorrhagic gastric ulcers in the rat. Rjpt gastro protective effect of standardized ethanolic. Therapeutic effect of momordica balsamina leaf extract on ethanolinduced gastric ulcer in wistar rats background. To evaluate the role of ala treatment on the healing of acetic acidinduced gastric ulcer, rats were given ala 35 mgkgday or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days early or 10 days late until they were decapitated. Evaluation of the antiulcer effect of aerva javanica.
The potentiating actions of cigarette smoking on ethanol. Gastric ulcer, protective effect, ethanol falcaria vulgaris locally named ghazzyaghi poghazeh is a member of umbelliferae family which grows near farmlands and is consumed as a vegetable in some regions of iran. Mechanisms of gastroprotective effects of ethanolic leaf. Antiulcer activity of swietenia mahagoni leaf extract in ethanolinduced gastric mucosal damage in rats. Further, the extract administration to rats resulted in an increase in levels of gastric glutathione and a decrease in alkaline phosphatase activity. Taken together, the findings of this research amply demonstrated that weac exerted appreciable gastroprotective effect against ethanolinduced gastric ulcer in rats. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, adoekiti were used. Ulcer can be induced by administration of hpylori, nonsteroidal antiinflammatory drugs and by environmental and life style factors prabhu and shivani 2014. All the animals were fasted for 36 hours before administration of ethanol.
Results antiulcer study gross estimations the results that pretreated with c. Ulceration was induced by oral administration of absolute ethanol 1cm3kg body weight. In acute toxicity study, a high dose of gkg did not manifest any toxicological signs in rats. Research article gastroprotective effects of lion s mane mushroom hericium erinaceus bullfr. The results of the current research revealed that following fed the rats with biochanin a the protein concentration preserved in the homogenate stomach tissue. Exposure of rats to ethanol resulted in gastric mucosal injury and a high index of ulcer. Ethanolinduced rodent gastric ulcer model creative biolabs. Relationship between ethanolinduced gastritis and gastric ulcer. Aphyllophoromycetideae extract against ethanolinduced ulcer in rats jingyangwong, 1,2 mahmoodameenabdulla, 1,3 jegadeeshraman, 1 chiaweiphan, 1,2 umahranikuppusamy, 1,3 shahramgolbabapour, 2,3 andvikineswarysabaratnam 1,3. The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts of j. Diazoxide, a katp channel opener, prevented ethanol. Antiulcerogenic effect of camel milk against ethanol induced. Diosmin protects against ethanolinduced gastric injury in. Evaluation of gastroprotective activity of myristica.
Antiulcerogenic effect of camel milk against ethanol. Amelioration of ethanolinduced gastric ulcers in rats. Pdf protective role of phoenix dactylifera fruit against. Sapindaceae, in a concentration dependant manner 200600 mgkg inhibited gastric ulcers induced by oral administration of absolute ethanol. Ethanolinduced gastric ulceration in rats semantic scholar. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. Studies on the mechanism of ethanolinduced gastric damage. The gastric ulcers were induced in rats of either sex weighing between 150 g by administrating absolute ethanol 8 mlkg. At creative biolabs, we offer ethanolinduced gastric ulcer models induced in both rats and mice. Roles of nitric oxide in protective effect of berberine in. Antiulcerogenic activity of scutia buxifolia on gastric. Gastric ulcers were induced by oral ingestion of ethanol. October 1997 smokingethanol and gastric mucosal damage 1189 potentiate both ethanol and stressinduced gastric muexperiment. Antioxidative and antiinflammatory effects of water.
Acute gastritis or gastric ulcer was induced in the rat stomach by 80% ethanol or 60% acetic acid, respectively. Therapeutic effect of low molecular weight chitosan. Ethanolinduced gastric ulcer in rats and intervention of. Ethanolinduced gu in animal model resembles the pathophysiology of human ulcer.
Results showed that rats pretreated with omeprazole or j. See desquamated mucosal cells red arrows from the surface of epithelium and. Normal saline and ranitidine were used as negative and positive control. Cyathula prostrata on ethanol induced gastric ulcer in rats ethanol induced ulcer in rats were valuated as described by ode and asuzu 2011 15. Mechanisms of gastroprotective effects of ethanolic leaf extract of. Effect of cardiospermum halicacabum on ethanolinduced. Therapeutic effect of momordica balsamina leaf extract on. Peptic ulcers are gastrointestinal lesions that occur in the stomach and duodenum as a result of ethanol consumption, helicobacter pylori infection and use of nonsteroidal antiinflammatory drugs. Zingerone is an ingredient of ginger zingiber officinale with different pharmacological activities. Gastroprotective effect of zingerone on ethanolinduced.
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